Endocrine Abstracts

Background: Testosterone replacement therapy in severe hypogonadism is indicated, however, the treatment of late onset hypogonadism (LOH) is debated, especially what the diagnostic criteria should be. In LOH bio-available testosterone probably gives a more accurate index of gonadal status as a diagnostic criterion as it takes SHBG into consideration. SHBG is known to increase with ageing, however, SHBG is also negatively influenced by insulin and visceral adiposity.<p clas...

Lowered testosterone levels may be observed in up to 50% of ageing men with type 2 diabetes (T2D). Testosterone replacement therapy (TRT) increases lean body mass in men with lowered testosterone levels and T2D, but the effect of TRT on glucose metabolism has not been evaluated by euglycemic hyperinsulinemic clamp.We used gold standard methods to evaluate the effect of TRT on body composition, insulin sensitivity, and oxidative metabolism in men with T2D...